MiR-19b/20a/92a regulates the self-renewal and proliferation of gastric cancer stem cells Running title: miR-19b/20a/92a regulate self-renewal
نویسندگان
چکیده
1 State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi’an, Shaanxi, 710032,China 2 Ningxia Medical University Affiliated Hospital, Yinchuan, Ningxia, 750004, China. 3 These authors contributed equally to this work. Correspondence State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi’an 710032, China Tel: +86 29 84771501 Fax: +86 29 82539041 E-mail: [email protected] (Daiming Fan), [email protected] (Yongquan Shi)
منابع مشابه
MiR-19b/20a/92a regulates the self-renewal and proliferation of gastric cancer stem cells.
Human gastric cancers contain a population of gastric cancer stem cells (GCSCs) that can undergo self-renewal and multipotent differentiation. GCSCs can be enriched with EpCAM+/CD44+ gastric cancer cells. However, the underlying mechanisms controlling the balance of GCSC self-renewal and differentiation remain to be explored. Because miRNAs can regulate cancer cell fates, we compared miRNA expr...
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We aimed to analyze the in vitro and in vivo effects of miRNA-19b/20a/92a on gastric cancer stem cells (GCSCs) and the related mechanism. GCSCs were cultured until adherence and differentiation, and subjected to miRNA microarray analysis to find and to verify miRNA deletion. Cells stably expressing lentivirus carrying miRNA-19b/20a/92a were constructed by transfection. The relationship between ...
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